Don't know if this is a hardware problem, software, or both. We are using an Agilent 1200 HPLC interfaced with a LabLogic Model 5 radiometric detector (B-RAM) via an Agilent 35900 analog-digital converter, for analysis of 14C-labeled materials. While we've got the LabLogic Laura software installed, we are using ChemStation to control the runs and integrate the B-RAM peaks, via the ADC box. We have been getting some very strange results lately. With seemingly random samples we are getting radioactivity counts that are 2, 3, 4, or even 5 times higher than expected. In addition, the B-RAM peaks are distorted, with large "spikes", with heights that are many multiples of comparable samples, or even the same sample from a different injection. The UV peaks are consistent and well-shaped; the chromatograms from Laura show normally shaped peaks with expected and consistent counts, heights, areas. If anyone has any thoughts, I can send some pdfs of the chromatograms. Don't know how to insert an image here.