Determination of related substances in 1- tert-butylamino -3- chloro -2- propanol hydrochloride
Gas phase: solvent dissolved sample, gas phase injection, sample tail serious, peak shape very poor. After neutralization with alkali, gas phase detection, under high temperature conditions, the sample is unstable, high impurities, sample detection does not reproduce.
Liquid phase: the sample has no UV absorption, and the CAD detector has low sensitivity, only the sample peak and the peak of tert-butylamine after acidification.
Would like to ask if there is a better detection method recommended?