Base-Deactivated End-Capped Column

[syx]

To use "base-deactivated" together with endcapping is marketing doublespeak. It means nothing.

Dear Mr. Neue,
BP2004 said: base-deactivated end-capped ... (You may see general monography for Tramadol HCl). Please give me explanation about this.

Best regards,
SYX

[Uwe Neue]

It is gobbledigook copied from the brochure of a column manufacturer who is marketing his product as "base deactivated".

I have previously said that for some base deactivated products it can be demonstrated that they are base deactivated using a special basic silane for endcapping. For other "base-deactivated" products, apparently including the ones that Steve was talking about, it is an arbitrary marketing label. I have jokingly referred to these products as the type, where a bottle of base is waved over the reactor during the reaction.

From a realistic standpoint, what will satisfy your need is a modern C18 based on a high-purity C18 that shows minimal silanol group activity. Which is something that can be measured...

[Uwe Neue]

I also should have said that well endcapped products based on a high-purity silica can nowadays be purchased from any reputable column supplier. No magic there ....

[HW Mueller]

It seems, though, that some suppliers are blocked by arrogance, it will take more than magic to have them do their homework. I have seen some go down with flying colors on this side of the ocean.