Chromatography Forum

Posted: **Fri Jan 04, 2013 9:57 am**

Just a simple question?

Is it normal for the pressure to go down when I increase the ACN concentration for example from 20% to 50%?

My pressure goes down from 130 bar to 120 bar.

Thanks

Posted: **Fri Jan 04, 2013 10:45 am**

Simple answer: Yes

Acetonitrile has a lower viscosity than water. The higher the ACN content in your eluent, the lower the viscosity and thus the backpressure will be.
Other organic solvents might show different characteristics. Especially methanol is a different story...

Posted: **Fri Jan 04, 2013 11:13 am**

Thanks

Chromatography Forum

Pressure and ACN

Pressure and ACN

Re: Pressure and ACN

Re: Pressure and ACN