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TOF for Pain Management
Posted: Mon Nov 24, 2014 11:06 pm
by mabrams0828
If you are performing addictive medicine and Pain Management Toxicology, using ONLY TOF mass spec, is this a good idea? Personally I believe you should also use a triple quad.
What is the consensus on this? is a TOF enough?
Thanks.
Martin
Re: TOF for Pain Management
Posted: Tue Nov 25, 2014 7:39 pm
by leadazide
I would think single MS could be enough.. if your TOF is HRAM capable this does give a very good selectivity.. if you also can do MS/MS with your TOF I would say your are better off then with a triple quad..
In my opinion standard triple quads are SO last century..
Re: TOF for Pain Management
Posted: Wed Nov 26, 2014 7:01 am
by Peter Apps
The MS is the last in the line of a long string of analytical chemistry - so the answer depends on how you are doing the sample prep, what exactly you are looking for (metabolites vs active) etc etc.
Peter
Re: TOF for Pain Management
Posted: Fri Nov 28, 2014 10:31 am
by nbik
You are not interesting in GC-MS (qqq or q-tof)? It's now very popular instrument for toxicology.
Also i read about bruker's toxtyper ion trap. Looks like good solution for your tasks.