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Ion suppression by THF in ESI?

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

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Ion suppression by THF in ESI?

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jusuom
What are your opinions on this issue? How bad is the ion suppression if THF is used as part of the HPLC eluent (e.g. 5%)?

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Kostas Petritis
I haven't heard of any ion suppression issues when using THF in such small %. Are you sure you don't mix it up with TFA?
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