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Ion suppression by THF in ESI?

Posted: Tue Jul 15, 2008 7:43 am
by jusuom
What are your opinions on this issue? How bad is the ion suppression if THF is used as part of the HPLC eluent (e.g. 5%)?

Posted: Tue Jul 15, 2008 2:55 pm
by Kostas Petritis
I haven't heard of any ion suppression issues when using THF in such small %. Are you sure you don't mix it up with TFA?